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Laboratory Director

David M. Jablons, M.D.
Professor of Surgery

Director, Thoracic Oncology Lab

Lung Cancer Systems Genetics

An Approach to Individualized Lung Cancer Diagnosis & Therapy

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Your gift to the Thoracic Oncology Lab helps scientists discover new treatments and cures for lung cancer, esophegeal cancer and mesothelioma.

Publications

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Gao Z, Xu Z, Hung MS, Lin YC, Wang T, Gong M, Zhi X, Jablons DM, You L
Procaine and procainamide inhibit the Wnt canonical pathway by promoter demethylation of WIF-1 in lung cancer cells.
Oncology reports, Dec-2009;22(6):1479-84.
Lemjabbar-Alaoui H, van Zante A, Singer MS, Xue Q, Wang YQ, Tsay D, He B, Jablons DM, Rosen SD
Sulf-2, a heparan sulfate endosulfatase, promotes human lung carcinogenesis.
Oncogene, Oct-26-2009;[Epub ahead of print].
Ray MR, Jablons DM
Hallmarks of Metastasis
Lung Cancer Metastasis, Sep-18-2009;10.1007/978-1-4419-0772-1(Springer, New York):29-46.
Yagui-Beltrán A, Jablons DM
A translational approach to lung cancer research: From EGFRs to Wnt and cancer stem cells.
Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia, Aug-2009;15(4):213-20.
Kratz JR, Jablons DM
Genomic prognostic models in early-stage lung cancer.
Clinical lung cancer, May-2009;10(3):151-7.
Kashani-Sabet M, Rangel J, Torabian S, Nosrati M, Simko J, Jablons DM, Moore DH, Haqq C, Miller JR, Sagebiel RW
A multi-marker assay to distinguish malignant melanomas from benign nevi.
Proceedings of the National Academy of Sciences of the United States of America, Apr-14-2009;106(15):6268-72.  Epub 2009 Mar 30.
Hung MS, Xu Z, Lin YC, Mao JH, Yang CT, Chang PJ, Jablons DM, You L
Identification of hematein as a novel inhibitor of protein kinase CK2 from a natural product library.
BMC cancer, 2009;[epublish]9:135.
Raz DJ, Gomez SL, Chang ET, Kim JY, Keegan TH, Pham J, Kukreja J, Hiatt RA, Jablons DM
Epidemiology of non-small cell lung cancer in Asian Americans: incidence patterns among six subgroups by nativity.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, Dec-2008;3(12):1391-7.
Yagui-Beltran, A., He, B., & Jablons, D.M.
Exploiting the Human Immune System for Lung Cancer Therapy
U.S. Oncology, 2008;[In Press].
Wilson SM, Barbone D, Yang TM, Jablons DM, Bueno R, Sugarbaker DJ, Nishimura SL, Gordon GJ, Broaddus VC
mTOR mediates survival signals in malignant mesothelioma grown as tumor fragment spheroids.
American journal of respiratory cell and molecular biology, Nov-2008;39(5):576-83.
Yagui-Beltrán A, He B, Jablons DM
The role of cancer stem cells in neoplasia of the lung: past, present and future.
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, Nov-2008;10(11):719-25.
To MD, Wong CE, Karnezis AN, Del Rosario R, Di Lauro R, Balmain A
Kras regulatory elements and exon 4A determine mutation specificity in lung cancer.
Nature genetics, Oct-2008;40(10):1240-4.  Epub 2008 Aug 31.
Okamoto J, Mikami I, Tominaga Y, Kuchenbecker KM, Lin YC, Bravo DT, Clement G, Yagui-Beltran A, Ray MR, Koizumi K, He B, Jablons DM
Inhibition of Hsp90 leads to cell cycle arrest and apoptosis in human malignant pleural mesothelioma.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, Oct-2008;3(10):1089-95.
Raz DJ, Ray MR, Kim JY, He B, Taron M, Skrzypski M, Segal M, Gandara DR, Rosell R, Jablons DM
A multigene assay is prognostic of survival in patients with early-stage lung adenocarcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research, Sep-1-2008;14(17):5565-70.
Skrzypski M, Jassem E, Taron M, Sanchez JJ, Mendez P, Rzyman W, Gulida G, Raz D, Jablons D, Provencio M, Massuti B, Chaib I, Perez-Roca L, Jassem J, Rosell R
Three-gene expression signature predicts survival in early-stage squamous cell carcinoma of the lung.
Clinical cancer research : an official journal of the American Association for Cancer Research, Aug-1-2008;14(15):4794-9.
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