Thoracic Oncology Laboratory »  Alumni »  Postdoctoral Fellows »  Trevor A. Graham, Ph.D.
Trevor A. Graham, Ph.D.

Trevor A. Graham, Ph.D.

Postdoctoral Fellow

Contact Information

Helen Diller Family Comprehensive Cancer Center
Department of Surgery
University of California, San Francisco
2340 Sutter St. Box 1351
San Francisco, CA 94115
trevor.graham@ucsfmedctr.org
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  • Imperial College London, UK, MSci Mathematics 2002
  • University College London, UK, MRes Modelling Biological Complexity, 2004
  • University College London, UK, PhD Mathematical Biology, 2008
  • Cancer Research UK London Research Institute, UK, Postdoctoral Research Fellow 2008-2011
  • UCSF, CA, USA, Postdoctoral Research Fellow, 2011-current
  • Barts Cancer Centre, QMUL, London, UK, Group leader, autumn 2013-onwards
  • Bioinformatics
  • Clonal evolution in cancer
  • Colon cancer
  • Intestinal stem cells
  • Lung cancer
  • Mathematical biology

I originally trained as a mathematician, and during my PhD and postdoctoral training I spent lots of time in genetics and pathology labs working at the lab-bench. In my day-to-day work I develop and use a variety of mathematical, statistics and wet-lab molecular biology (mainly genetics) techniques. The clonal evolution of cancer has been the focus of my research since the beginning of my PhD training.

I research clonal evolution in cancer. I spend most of time my trying to measure the rate of evolution within cancers and in premalignant lesions. I try to use these measures to predict prognosis for established cancers, and the risk of developing cancer in premalignant lesions. I'm interested in the patterns of evolution that shape carcinogenesis, and these patterns are determined by mutational processes and the histological structure of tissues that constrains clonal expansions.

  1. S Datta R, Gutteridge A, Swanton C, Maley CC, Graham TA. Modelling the evolution of genetic instability during tumour progression. Evol Appl. 2013 Jan; 6(1):20-33.
  2. Gilbertson RJ, Graham TA. Cancer: Resolving the stem-cell debate. Nature. 2012 Aug 23; 488(7412):462-3.
  3. Galandiuk S, Rodriguez-Justo M, Jeffery R, Nicholson AM, Cheng Y, Oukrif D, Elia G, Leedham SJ, McDonald SA, Wright NA, Graham TA. Field cancerization in the intestinal epithelium of patients with Crohn's ileocolitis. Gastroenterology. 2012 Apr; 142(4):855-864.e8.
  4. Thirlwell C, Will OC, Domingo E, Graham TA, McDonald SA, Oukrif D, Jeffrey R, Gorman M, Rodriguez-Justo M, Chin-Aleong J, Clark SK, Novelli MR, Jankowski JA, Wright NA, Tomlinson IP, Leedham SJ. Clonality assessment and clonal ordering of individual neoplastic crypts shows polyclonality of colorectal adenomas. Gastroenterology. 2010 Apr; 138(4):1441-54, 1454.e1-7.
    Use of methylation patterns to determine expansion of stem cell clones in human colon tissue
  5. Graham TA, Humphries A, Sanders T, Rodriguez-Justo M, Tadrous PJ, Preston SL, Novelli M, Leedham SJ, McDonald SAC, Wright NA Gastroenterology, April 2011, 140(4) 1241-1250

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