Thoracic Oncology Laboratory »  Alumni »  Specialists »  Hui Li, Ph.D.
Hui Li, Ph.D.

Hui Li, Ph.D.

Assistant Specialist

Contact Information

2340 Sutter St, Room N261
San Francisco, CA 94143-1724
(415) 502-2555
hui.li@ucsfmedctr.org
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  • 2009, Ph.D., Molecular,Cellular&Developmental Biology, Univeristy of Michigan, Ann Arbor
  • 2003, B.S., Biological Sciences, Tsinghua University, Beijing China
  • Cancer stem cells
  • Diagnostic, prognostic and predictive biomarkers
  • Hedgehog and Wnt signaling
  • Lung Cancer and mesothelioma
  • Novel small molecule inhibitors

Hui Li, Ph.D. joined the Thoracic Oncology Lab in 2009 as Assistant Specialist. Her research focus is to understand the role of Wnt and Hedgehog signaling pathways in human lung cancer and mesothelioma, and to develop novel small molecule inhibitors targeting Wnt and Hedgehog signaling pathways. The research will be focused on screening of small molecule library, cell-based assays, biochemical assays, mechanism analysis and animal studies.

Prior to UCSF, Dr. Hui has worked as an intern with the Office of Technology Transfer at the University of Michigan, Ann Arbor, where she developed commercialization plans for a novel biomaterial and a regenerative medicine.

Hui obtained a B.S. in Biological Sciences from Tsinghua University in China in 2003. and her Ph.D. in Molecular, Cellular & Developmental Biology from the University of Michigan, Ann Arbor in 2009 with Prof. Ken Cadigan. Her research was focused on the Wnt signaling pathway and apoptosis in the fruit fly Drosophila. Her dissertation was entitled as "The Regulation of Drosophila Inhibitor of Apoptosis Protein I in Apoptosis and Cell Survival".

Clement G, Zhang F, Chen Z, Zhou HM, Li H, Sheng Q, Mikami I, Kinoshita H, Shi Y, Beltran A, Lui N, Do HT, Fujii N, Jablons D and He B. Targeting the Gli transcription activation domain by small molecules suppresses tumor cell growth. Oncogene

Li H, Lui N, Cheng T, Tseng HH, Yue D, Giroux-Leprieur E, Do HT, Sheng Q, Jin JQ, Luh TW,Jablons DM, He B.Gli as a novel therapeutic target in malignant pleural mesothelioma. PloS One(2013) 8(3):e57346

Zhang Y, He J, Zhang F, Li H, Yue D, Wang C, Jablons DM, He B, Lui N.SMO expression level correlates with overall survival in patients with malignant pleural mesothelioma.J Exp Clin Cancer Res. 2013 Feb 5;32(1):7.

Li J, Mo M, Chen Z, Chen Z, Sheng Q, Mu H, Zhang F, Zhang Y, Zhi XY, Li H, He B, Zhou HM. Adenoviral delivery of the EMX2 gene suppresses growth in human gastric cancer.PLoS One. 2012;7(9):e45970.

Okamoto J, Hirata T, Chen Z, Zhou HM, Mikami I, Li H, Yagui-Beltran A, Johansson M, Coussens LM, Clement G, Shi Y, Zhang F, Koizumi K, Shimizu K, Jablons D, He B. EMX2 is epigenetically silenced and suppresses growth in human lung cancer Oncogene (2011) 29(44) : 5965-79

Okamoto J, Kratz JR, Hirata T, Mikami I, Raz D, Segal M, Chen Z, Zhou HM, Pham P, Li H, Yagui-Beltran A, Ray MR, Koizumi K, Shimizu K, Jablons D, He B. Downregulation of EMX2 is associated with clinical outcomes in lung adenocarcinoma patients.Clin Lung Cancer. 2011 Jul;12(4):237-44

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