Thoracic Oncology Laboratory
Related Sites
Dept. of Surgery Websites

Laboratory Director

David M. Jablons, M.D.
Professor of Surgery
Program Leader,
Thoracic Oncology Program
Director, Thoracic Oncology Lab

Support the Lab

A gift to the Thoracic Oncology Lab helps us discover new treatments and cures for lung cancer, esophageal cancer and mesothelioma.

Research Fellow Johannes Kratz, M.D. Leaves Lasting Mark on Lab

Johannes Kratz, M.D., a research fellow in the Thoracic Oncology Lab from 2008-11, played a pivotal role in the development of a prognostic assay for early-stage lung cancer patients, reported on in The Lancet and JAMA.   

On the road to discovery.... Diagnostics Development, Molecularly-Targeted Therapeutics

Cancer treatment is rapidly proceeding towards the era of personalized medicine where treatment is based on the distinctive molecular characteristics of a patient's tumor. This knowledge will allow patients to receive novel combinations of therapies that will maximize clinical benefit, more accurately predict disease outcome, and allow patients at the highest risk of relapse to receive the most aggressive treatment.

The Thoracic Oncology Lab is pursuing a variety of strategies to treat and cure lung cancer, mesothelioma and esophageal cancer. These include the investigation of molecular pathways such as Wnt and Hh, the role of inflammation in lung carcinogenesis, isolation of lung cancer stems cells, and the Lung Cancer Systems Genetics Project, An Approach to Individualized Lung Cancer Diagnosis and Therapy. Eventually, these efforts will have a major impact on these diseases.

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Recent Publications

Zhang S, Long H, Yang YL, Wang Y, Hsieh D, Li W, Au A, Stoppler HJ, Xu Z, Jablons DM, You L
Inhibition of CK2α down-regulates Notch1 signalling in lung cancer cells.
Journal of cellular and molecular medicine, May-08-2013; [Epub ahead of print].
Kratz JR, Tham PT, Mulvihill MS, Ziaei F, Ray MR, Hurst JW, Segal MR, Berryman DM, Chu W, He B, Jablons DM, Mann MJ
Analytical Validation of a Practical Molecular Assay Prognostic of Survival in Nonsquamous Non-Small Cell Lung Cancer.
Diagnostic molecular pathology : the American journal of surgical pathology, part B, Apr-25-2013; [Epub ahead of print].
Kim IJ, Quigley D, To MD, Pham P, Lin K, Jo B, Jen KY, Raz D, Kim J, Mao JH, Jablons D, Balmain A
Rewiring of human lung cell lineage and mitotic networks in lung adenocarcinomas.
Nature communications, Apr-16-2013; 4: 1701.
Mulvihill MS, Kratz JR, Pham P, Jablons DM, He B
The role of stem cells in airway repair: implications for the origins of lung cancer.
Chinese journal of cancer, Feb-01-2013; 322: 71-4.  Epub 2012 Nov 1.
Li H, Lui N, Cheng T, Tseng HH, Yue D, Giroux-Leprieur E, Do HT, Sheng Q, Jin JQ, Luh TW, Jablons DM, He B
Gli as a novel therapeutic target in malignant pleural mesothelioma.
PloS one, 83: e57346.
Zhang Y, He J, Zhang F, Li H, Yue D, Wang C, Jablons DM, He B, Lui N
SMO expression level correlates with overall survival in patients with malignant pleural mesothelioma.
Journal of experimental & clinical cancer research : CR, [epublish] 32: 7.
Xi Y, Wei Y, Sennino B, Ulsamer A, Kwan I, Brumwell AN, Tan K, Aghi MK, McDonald DM, Jablons DM, Chapman HA
Identification of pY654-β-catenin as a critical co-factor in hypoxia-inducible factor-1α signaling and tumor responses to hypoxia.
Oncogene, Dec-17-2012; [Epub ahead of print].
Kratz JR, Van den Eeden SK, He J, Jablons DM, Mann MJ
A prognostic assay to identify patients at high risk of mortality despite small, node-negative lung tumors.
JAMA : the journal of the American Medical Association, Oct-24-2012; 30816: 1629-31.
Kim JW, Lee S, Lui N, Choi H, Mulvihill M, Fang LT, Kang HC, Kwon YW, Jablons D, Kim IJ
A somatic TSHR mutation in a patient with lung adenocarcinoma with bronchioloalveolar carcinoma, coronary artery disease and severe chronic obstructive pulmonary disease.
Oncology reports, Oct-01-2012; 284: 1225-30.  Epub 2012 Jul 26.
Li T, Hou SC, Mao JH, Wang YC, Lu XD, Tan JL, You B, Liu YP, Ni J, Au A, Jablons DM, Xu Z, You L
The expression of Dishevelled-3 and glutamine metabolism in malignant pleural mesothelioma.
Journal of clinical pathology, Sep-01-2012; 659: 855-8.  Epub 2012 May 8.
Choi H, Kratz J, Pham P, Lee S, Ray R, Kwon YW, Mao JH, Kang HC, Jablons D, Kim IJ
Development of a rapid and practical mutation screening assay for human lung adenocarcinoma.
International journal of oncology, Jun-01-2012; 406: 1900-6.  Epub 2012 Mar 07.
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