Thoracic Oncology Laboratory

On the road to discovery.... Diagnostics Development, Molecularly-Targeted Therapeutics

Cancer treatment is rapidly proceeding towards the era of personalized medicine where treatment is based on the distinctive molecular characteristics of a patient's tumor. This knowledge will allow patients to receive novel combinations of therapies that will maximize clinical benefit, more accurately predict disease outcome, and allow patients at the highest risk of relapse to receive the most aggressive treatment.

The Thoracic Oncology Lab is pursuing a variety of strategies to treat and cure lung cancer, mesothelioma and esophageal cancer. These include the investigation of molecular pathways such as Wnt and Hh, the role of inflammation in lung carcinogenesis, isolation of lung cancer stems cells, and the Lung Cancer Systems Genetics Project, An Approach to Individualized Lung Cancer Diagnosis and Therapy. Eventually, these efforts will have a major impact on these diseases.

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Recent Publications

Mo ML, Ma J, Chen Z, Wei B, Li H, Zhou Y, Shi H, Tolani B, Jin JQ, Tseng HH, Shen D, Zhan Y, Li J, Jablons DM, Zhang RQ, Guo Y, He B, Zhou HM
Measurement of genome-wide DNA methylation predicts survival benefits from chemotherapy in non-small cell lung cancer.
Journal of cancer research and clinical oncology, Nov-04-2014; [Epub ahead of print].
Capelletti M, Dodge ME, Ercan D, Hammerman PS, Park SI, Kim J, Sasaki H, Jablons DM, Lipson D, Young L, Stephens PJ, Miller VA, Lindeman N, Munir KJ, Richards WG, Janne PA
Identification of recurrent FGFR3-TACC3 fusion oncogenes from lung adenocarcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research, Oct-07-2014; [Epub ahead of print].
Woodard GA, Gubens MA, Jahan TM, Jones KD, Kukreja J, Theodore PR, Cardozo S, Jew G, Clary-Macy C, Jablons DM, Mann MJ
Prognostic Molecular Assay Might Improve Identification of Patients At Risk for Recurrence in Early-Stage Non-Small-Cell Lung Cancer.
Clinical lung cancer, Aug-15-2014; [Epub ahead of print].
Giroux Leprieur E, Hirata T, Mo M, Chen Z, Okamoto J, Clement G, Li H, Wislez M, Jablons DM, He B
The homeobox gene EMX2 is a prognostic and predictive marker in malignant pleural mesothelioma.
Lung cancer (Amsterdam, Netherlands), Jun-30-2014; [Epub ahead of print].
Bosco-Clément G, Zhang F, Chen Z, Zhou HM, Li H, Mikami I, Hirata T, Yagui-Beltran A, Lui N, Do HT, Cheng T, Tseng HH, Choi H, Fang LT, Kim IJ, Yue D, Wang C, Zheng Q, Fujii N, Mann M, Jablons DM, He B
Targeting Gli transcription activation by small molecule suppresses tumor growth.
Oncogene, Apr-17-2014; 3316: 2087-97.  Epub 2013 May 20.
Wang Y, Wen M, Kwon Y, Xu Y, Liu Y, Zhang P, He X, Wang Q, Huang Y, Jen KY, LaBarge MA, You L, Kogan SC, Gray JW, Mao JH, Wei G
CUL4A induces epithelial-mesenchymal transition and promotes cancer metastasis by regulating ZEB1 expression.
Cancer research, Jan-15-2014; 742: 520-31.  Epub 2014 Jan 9.
Hung MS, Xu Z, Chen Y, Smith E, Mao JH, Hsieh D, Lin YC, Yang CT, Jablons DM, You L
Hematein, a casein kinase II inhibitor, inhibits lung cancer tumor growth in a murine xenograft model.
International journal of oncology, Nov-01-2013; 435: 1517-22.  Epub 2013 Sep 04.
Fang LT, Lee S, Choi H, Kim HK, Jew G, Kang HC, Chen L, Jablons D, Kim IJ
Comprehensive genomic analyses of a metastatic colon cancer to the lung by whole exome sequencing and gene expression analysis.
International journal of oncology, Oct-25-2013; [Epub ahead of print].
Xi Y, Wei Y, Sennino B, Ulsamer A, Kwan I, Brumwell AN, Tan K, Aghi MK, McDonald DM, Jablons DM, Chapman HA
Identification of pY654-β-catenin as a critical co-factor in hypoxia-inducible factor-1α signaling and tumor responses to hypoxia.
Oncogene, Oct-17-2013; 3242: 5048-57.  Epub 2012 Dec 17.
Ganesan AP, Johansson M, Ruffell B, Beltran A, Lau J, Jablons DM, Coussens LM
Tumor-infiltrating regulatory T cells inhibit endogenous cytotoxic T cell responses to lung adenocarcinoma.
Journal of immunology (Baltimore, Md. : 1950), Aug-15-2013; 1914: 2009-17.  Epub 2013 Jul 12.
Zhang S, Long H, Yang YL, Wang Y, Hsieh D, Li W, Au A, Stoppler HJ, Xu Z, Jablons DM, You L
Inhibition of CK2α down-regulates Notch1 signalling in lung cancer cells.
Journal of cellular and molecular medicine, Jul-01-2013; 177: 854-62.  Epub 2013 May 8.
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