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On the road to discovery.... Diagnostics Development, Molecularly-Targeted Therapeutics

Cancer treatment is rapidly proceeding towards the era of personalized medicine where treatment is based on the distinctive molecular characteristics of a patient's tumor. This knowledge will allow patients to receive novel combinations of therapies that will maximize clinical benefit, more accurately predict disease outcome, and allow patients at the highest risk of relapse to receive the most aggressive treatment.

The Thoracic Oncology Lab is pursuing a variety of strategies to treat and cure lung cancer, mesothelioma and esophageal cancer. These include the investigation of molecular pathways such as Wnt and Hh, the role of inflammation in lung carcinogenesis, isolation of lung cancer stems cells, and the Lung Cancer Systems Genetics Project, An Approach to Individualized Lung Cancer Diagnosis and Therapy. Eventually, these efforts will have a major impact on these diseases.

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Recent Publications

Yang YL, Ni J, Hsu PC, Mao JH, Hsieh D, Xu A, Chan G, Au A, Xu Z, Jablons DM, You L
Cul4A overexpression associated with Gli1 expression in malignant pleural mesothelioma.
Journal of cellular and molecular medicine, Jul-27-2015; [Epub ahead of print].
Wang Y, Xu Z, Mao JH, Hung MS, Hsieh D, Au A, Jablons DM, You L
Analysis of lung tumor initiation and progression in transgenic mice for Cre-inducible overexpression of Cul4A gene.
Thoracic cancer, Jul-01-2015; 64: 480-7.
Wang Y, Xu Z, Mao JH, Hsieh D, Au A, Jablons DM, Li H, You L
PR-Set7 is Degraded in a Conditional Cul4A Transgenic Mouse Model of Lung Cancer.
Zhongguo fei ai za zhi = Chinese journal of lung cancer, Jun-20-2015; 186: 345-50.
Yeh CC, Fan Y, Jiang L, Yang YL, He B, You L, Mann M
Genistein Suppresses Growth of Human Uterine Sarcoma Cell Lines via Multiple Mechanisms.
Anticancer research, Jun-01-2015; 356: 3167-73.
Blakely CM, Pazarentzos E, Olivas V, Asthana S, Yan JJ, Tan I, Hrustanovic G, Chan E, Lin L, Neel DS, Newton W, Bobb KL, Fouts TR, Meshulam J, Gubens MA, Jablons DM, Johnson JR, Bandyopadhyay S, Krogan NJ, Bivona TG
NF-κB-Activating Complex Engaged in Response to EGFR Oncogene Inhibition Drives Tumor Cell Survival and Residual Disease in Lung Cancer.
Cell reports, Apr-07-2015; 111: 98-110.  Epub 2015 Apr 2.
You B, Yang YL, Xu Z, Dai Y, Liu S, Mao JH, Tetsu O, Li H, Jablons DM, You L
Inhibition of ERK1/2 down-regulates the Hippo/YAP signaling pathway in human NSCLC cells.
Oncotarget, Jan-23-2015; [Epub ahead of print].
Letteboer TG, Benzinou M, Merrick CB, Quigley DA, Zhau K, Kim IJ, To MD, Jablons DM, van Amstel JK, Westermann CJ, Giraud S, Dupuis-Girod S, Lesca G, Berg JH, Balmain A, Akhurst RJ
Genetic variation in the functional ENG allele inherited from the non-affected parent associates with presence of pulmonary arteriovenous malformation in hereditary hemorrhagic telangiectasia 1 (HHT1) and may influence expression of PTPN14.
Frontiers in genetics, [epublish] 6: 67.
Woodard GA, Jablons DM
The Latest in Surgical Management of Stage IIIA Non-Small Cell Lung Cancer: Video-Assisted Thoracic Surgery and Tumor Molecular Profiling.
American Society of Clinical Oncology educational book / ASCO. American Society of Clinical Oncology. Meeting, 35: e435-41.
Yue D, Li H, Che J, Zhang Y, Tolani B, Mo M, Zhang H, Zheng Q, Yang Y, Cheng R, Jin JQ, Luh TW, Yang C, Tseng HH, Giroux-Leprieur E, Woodard GA, Hao X, Wang C, Jablons DM, He B
EMX2 Is a Predictive Marker for Adjuvant Chemotherapy in Lung Squamous Cell Carcinomas.
PloS one, [epublish] 107: e0132134.
Zhang S, Yang YL, Wang Y, You B, Dai Y, Chan G, Hsieh D, Kim IJ, Fang L, Au A, Stoppler HJ, Xu Z, Jablons DM, You L
CK2¿, over-expressed in human malignant pleural mesothelioma, regulates the Hedgehog signaling pathway in mesothelioma cells.
Journal of experimental & clinical cancer research : CR, Nov-25-2014; [Epub ahead of print] 331: 93.
Mo ML, Ma J, Chen Z, Wei B, Li H, Zhou Y, Shi H, Tolani B, Jin JQ, Tseng HH, Shen D, Zhan Y, Li J, Jablons DM, Zhang RQ, Guo Y, He B, Zhou HM
Measurement of genome-wide DNA methylation predicts survival benefits from chemotherapy in non-small cell lung cancer.
Journal of cancer research and clinical oncology, Nov-04-2014; [Epub ahead of print].
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