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Laboratory Director

David M. Jablons, M.D.
Professor of Surgery

Director, Thoracic Oncology Lab

Lung Cancer Systems Genetics

An Approach to Individualized Lung Cancer Diagnosis & Therapy

Support the Lab

Your gift to the Thoracic Oncology Lab helps scientists discover new treatments and cures for lung cancer, esophegeal cancer and mesothelioma.

On the road to discovery.... Wnt Signalling, Diagnostics Development, Molecular Targeted Therapeutics

Cancer treatment is rapidly proceeding towards the era of personalized medicine where treatment is based on the distinctive molecular characteristics of a patient's tumor. This knowledge will allow patients to receive novel combinations of therapies that will maximize clinical benefit, more accurately predict disease outcome, and allow patients at the highest risk of relapse to receive the most aggressive treatment.

The Thoracic Oncology Lab is pursuing a variety of strategies to treat and cure lung cancer, mesothelioma and esophageal cancer. These include the investigation of molecular pathways such as Wnt and Hh, the role of inflammation in lung carcinogenesis, isolation of lung cancer stems cells, and the Lung Cancer Systems Genetics Project, An Approach to Individualized Lung Cancer Diagnosis and Therapy. Eventually, these efforts will have a major impact on these diseases.

Featured Publications

Gao Z, Xu Z, Hung MS, Lin YC, Wang T, Gong M, Zhi X, Jablons DM, You L
Procaine and procainamide inhibit the Wnt canonical pathway by promoter demethylation of WIF-1 in lung cancer cells.
Oncology reports, Dec-01-2009; 226: 1479-84.
Lemjabbar-Alaoui H, van Zante A, Singer MS, Xue Q, Wang YQ, Tsay D, He B, Jablons DM, Rosen SD
Sulf-2, a heparan sulfate endosulfatase, promotes human lung carcinogenesis.
Oncogene, Oct-26-2009; [Epub ahead of print].
Ray MR, Jablons DM
Hallmarks of Metastasis.
Lung Cancer Metastasis, Sep-18-2009; 10.1007/978-1-4419-0772-1Springer, New York: 29-46.
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Yagui-Beltrán A, Jablons DM
A translational approach to lung cancer research: From EGFRs to Wnt and cancer stem cells.
Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia, Aug-01-2009; 154: 213-20.
Kratz JR, Jablons DM
Genomic prognostic models in early-stage lung cancer.
Clinical lung cancer, May-01-2009; 103: 151-7.
Kashani-Sabet M, Rangel J, Torabian S, Nosrati M, Simko J, Jablons DM, Moore DH, Haqq C, Miller JR, Sagebiel RW
A multi-marker assay to distinguish malignant melanomas from benign nevi.
Proceedings of the National Academy of Sciences of the United States of America, Apr-14-2009; 10615: 6268-72.  Epub 2009 Mar 30.
Hung MS, Xu Z, Lin YC, Mao JH, Yang CT, Chang PJ, Jablons DM, You L
Identification of hematein as a novel inhibitor of protein kinase CK2 from a natural product library.
BMC cancer, [epublish] 9: 135.
Raz DJ, Gomez SL, Chang ET, Kim JY, Keegan TH, Pham J, Kukreja J, Hiatt RA, Jablons DM
Epidemiology of non-small cell lung cancer in Asian Americans: incidence patterns among six subgroups by nativity.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, Dec-01-2008; 312: 1391-7.
Yagui-Beltran, A., He, B., & Jablons, D.M.
Exploiting the Human Immune System for Lung Cancer Therapy.
U.S. Oncology. [In Press].
Wilson SM, Barbone D, Yang TM, Jablons DM, Bueno R, Sugarbaker DJ, Nishimura SL, Gordon GJ, Broaddus VC
mTOR mediates survival signals in malignant mesothelioma grown as tumor fragment spheroids.
American journal of respiratory cell and molecular biology, Nov-01-2008; 395: 576-83.
Yagui-Beltrán A, He B, Jablons DM
The role of cancer stem cells in neoplasia of the lung: past, present and future.
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, Nov-01-2008; 1011: 719-25.
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